Our Research

Knoepfler Lab Knoepfler Lab Knoepfler Lab Knoepfler Lab Knoepfler Lab
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The Knoepfler Lab is interested in epigenetics and chromatin, and the cellular machinery that regulates these states normally in stem cells and aberrantly in cancer, particularly brain tumors. There are many, exciting open questions in these areas of research. For instance, what are the shared and distinct molecular events in normal and cancer stem cells? 

We use cutting edge molecular, cellular and developmental biology methods as well as genomic and gene editing technologies to attack these questions. We are particularly interested now in the roles that the MYC family, DPPA4, and the histone variant H3.3 in stem cells and cancer. How do these factors link together the epigenome to cellular behaviors and tissue growth? 

Our big picture goal is to impact human health through discoveries in cancer and stem cell biology. 

Join us! We are currently as of 2017 looking for a talented postdoctoral fellow to join our team, and we are always recruiting new graduate and undergraduate students as well.