Publications

2016

To CRISPR and beyond: the evolution of genome editing in stem cells. Chen KY, Knoepfler PS., Regen Med. 2016 Dec;11(8):801-816. PMID: 27905217

Turner L, Knoepfler P. Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry. Cell Stem Cell. 2016 Jun 29. pii: S1934-5909(16)30157-6. doi: 10.1016/j.stem.2016.06.007. [Epub ahead of print] PubMed PMID: 27374789.

Review of Stem Cell Dialogues by Sheldon Krimsky(1). Knoepfler PSAm J Bioeth. 2016 Apr;16(4):W12-3. doi: 10.1080/15265161.2016.1145756. 

When patients reach out, scientists should reach back carefully. Knoepfler PSNat Med. 2016 Mar 3;22(3):230. doi: 10.1038/nm0316-230.

 

2015

Reviewing post-publication peer review. Knoepfler P., Trends Genet. 2015 May;31(5):221-3. doi: 10.1016/j.tig.2015.03.006. Epub 2015 Apr 4.

From bench to FDA to bedside: US regulatory trends for new stem cell therapies. Knoepfler PS., Adv Drug Deliv Rev. 2015 Mar;82-83C:192-196. doi: 10.1016/j.addr.2014.12.001. Epub 2014 Dec 7. Review.

 

2014

Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler PS. Development. 2014 Aug 19. pii: dev.106450. [Epub ahead of print]

Miz-1 Activates Gene Expression via a Novel Consensus DNA Binding Motif.. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. PLoS One. 2014 Jul 1;9(7):e101151. doi: 10.1371/journal.pone.0101151. eCollection 2014.

Epigenetic mechanisms of tumorigenicity manifesting in stem cells.. Tung PY, Knoepfler PS. Oncogene. 2014 Jun 16;0. doi: 10.1038/onc.2014.172. [Epub ahead of print]

 

2013

Histone H3.3 Mutations: A Variant Path to Cancer. BTK Yuen, PS Knoepfler. Cancer cell 24 (5), 567-574.

Identification of DPPA4 and DPPA2 as a Novel Family of Pluripotency‐Related Oncogenes. PY Tung, NV Varlakhanova, PS Knoepfler. STEM CELLS 31 (11), 2330-2342.

Key Action Items for the Stem Cell Field: Looking Ahead to 2014. PS Knoepfler. Stem cells and development.

Scientists: you really need to get out of the lab more. Knoepfler PS. Nat Med. 2013 Sep 6;19(9):1086. doi: 10.1038/nm0913-1086.

Chromatin immunoprecipitation assays for myc and N-myc. Barrilleaux BL, Cotterman R, Knoepfler PS. The Myc Gene, 117-133.

Automation of Library Preparation for High-resolution ChIP-seq Profiling. IM Henry, R Cotterman, P Knoepfler, L Comai, RW Kim, H O'Geen. Journal of Biomolecular Techniques. 2013. JBT 24 (Suppl), S45.

Laskowski AI and Knoepfler PS. Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain. Biochemical and biophysical research communications.

Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Bush KM, Yuen BT, Barrilleaux BL, Riggs JW, O Geen H, Cotterman R, Knoepfler PS. Epigenetics Chromatin. 2013 Apr 9;6(1):7.

Riggs JW, Barrilleaux B, Varlakhanova N, Bush K, Chan V, and Knoepfler PS. Induced pluripotency and oncogenic transformation are related processes. Stem Cells & Dev. 2013 Jan 1;22(1):37-50.

Knoepfler PS. Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians. Regen Med. 2013 Mar;8(2):223-5.

 

2012

Meissen JK , Yuen BTK, Kind T, Riggs JW, Barupala DK, Knoepfler PK*, and Fiehn O*. Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One 2012;7(10):e46770.  *co-corresponding authors.

Laskowski AI and Knoepfler PS. Utf1: Goldilocks for ESC bivalency. Cell Stem Cell 2012; Dec 7;11(6):732-4.

Pshenichnaya I, Schouwey K, Armaro M, Larue L, Knoepfler PS, Eisenman RN, Trumpp A, Delmas V, and Beermann F. Constitutive gray hair in Mice induced by Melanocyte-specific deletion of c-Myc. 2012 Pigment Cell Melanoma Res. 2012 Mar 15.

Martínez-Cerdeño V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, and Knoepfler PS. N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS One. 2012;7(6):e39456.

Knoepfler PS. Key anticipated regulatory issues for clinical use of human induced pluripotent stem cells. Regenerative Medicine. 2012. 2012; Sep;7(5):713-20.

 

2011

Dominguez-Frutos E.,  Lopez Hernandez I., Vendrell V., Gallozzi M., Gutsche K., Sharpe J., Knoepfler PS, Eisenman RN, Trumpp A., and Schimmang T. N-myc controls proliferation, morphogenesis and patterning of the inner ear.  J. NeuroSci. 2011 31(19):7178-89.

Barrilleaux B. and Knoepfler PS. Overexpression of oncogenes in human cells using ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24;(53). 

Barrilleaux B. and Knoepfler PS. Inducing iPS cells to escape the dish. Cell Stem Cell.2011 Aug 5;9(2):103-11.

Varlakhanova NV, Cotterman RF, Bradnam K, Korf I, and Knoepfler PS. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics & Chromatin. 2011 Nov 4;4(1):20.

Knoepfler PS. My Year As A Stem Cell Blogger. Nature. 475(7357):425.

Barrilleaux B. and Knoepfler PS. Overexpression of oncogenes in human cells using ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24;(53). pii: 2822

Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T. N-myc Controls Proliferation, Morphogenesis, and Patterning of the Inner Ear. J. Neurosci 2011 31(19): 7178-7189.

 

2010

Varlakhanova N, Cotterman R, deVries W, Morgan J, Donahue LR, Murray S, Knowles BB, and Knoepfler PS. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation. 2010. 80(1):9-19.

Wey, A Ceredeno VM, Pleasure D, and Knoepfler PS. c-myc and N-myc regulate self-renewal, pluripotency, and metabolism of neural stem cells to direct brain growth.Cerebellum 2010 Dec;9(4):537-47.

Wey A, and Knoepfler PS. c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain. 2010. OncoTarget. 1(2), 1-10.

Wey A, and Knoepfler PS. C-myc and N-myc in the developing brain. Aging. 2010. 2(5):261-2.

Kuwahara A, Hirabayashi Y, Knoepfler PS, Taketo MM, Sakai J, Kodama T, Gotoh Y. Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development. 2010. 137(7):1035-44.

Knoepfler PS and Bush KM. Software for the efficient management of mouse colonies. Dis Model Mech. 2010 Jan-Feb;3(1-2):9-10.